I have to agree that skillshots wouldn't really be skillshots in PvE.
Personally I believe that glyphs would be the best way to change skills to make them skillshots. The example Lore gives about the paladin gap closer I think would be something cool if they had a glyph to change judgement to a skill shot that would launch the hammer (or sword/axe with minor glyph) in the direction that the paladin selects and then pull you to the target if it hits them on top of the other things judgement does.
Of course they could always add a couple talents that are skill shots, but then those talents would generally be completely ignored in PvE, which is not what they're going for unless it's a whole tier of skill shot talents like the hunters had. This is why I believe glyphs would be the best idea for it if they went that direction.
"Kyle, this is the way the world works. If you want to find quality friends, you have to wade through all the dicks first." -Cartman