First off a link to your armory would help greatly.
There is no need for DnD for single target. DnD is for AOE only. why would you not use runestrike macros? thats one less thing you have to worry about. If you're worried about not having enough RP to be usable try not spamming RP ablities as much and trying to keep RP by actually keeping an active eye on it but it most cases this shouldn't be needed.
Try removing DnD from your single target rotation and the RS macro to all your melee abilities.