Frame rate, if it is effecing your ability to use attacks will hurt. The same goes for extreme latency or poor reaction times.
Think about it this way, if you are a gcd locked class(like an enh shammy) taking the haste complication out of it, you get 1 special every 1.5 seconds. Now imagine your frame rate, latency (there are mechanisms to help this built into the game butmigt not help extreme cases) and slow reaction time all leads to yu taking half a second to press the next attack. You now get 1 attack every 2 seconds... Over a 3 minute fight that's 120 vs 90... That's huge.
I don't know Jack about locks but I know connection, system and reaction time affect dsp.


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