The observation about the frequency, as well as occurrence, of n-hit-strings is interesting, too. While the suggestion is that provided n-hit strings occur with sufficient infrequency that a cooldown is always available for them (assuming that said string is life-threatening and that using a cooldown negates the danger), there are two issues with this. Firstly, the suggestion is that one is able to reactively time cooldowns to co-incide with periods of danger, there's no way to know until the n-th hit lands that you were in a lethal situation, assuming that n-1 hits aren't going to be fatal and so you couldn't pre-empt the n-th. Secondly, just because the expected frequency were low wouldn't guarantee you wouldn't see back-to-back n-hit strings and thus not be able to time cooldowns---it's the same argument as with avoidance, expected damage taken or frequency is irrelevant since you can't survive the (potentially limited) number of times where these events do occur.
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