Rune Tap, but I think that's a personal call and depends on your survivability...or lack thereof. :-)
Spell Deflection is pretty situational and...I am not really sure about Mark of Blood and Sudden Doom. I think it might be that the benefit is not that much worth the cost, while the points may be better invested elsewhere?
I added the glyphs I used (link).
You may feel like substituting Glyph of Rune Strike with Glyph of Dark Command, and/or Glyph of Blood Tap with Glyph of Horn of Winter. While the first change - I believe - depends on whether you're having issues with Dark Command, the second is a somewhat random choice, but Blood Tap does use 6% of your base health.