Yes.
For example, with a double-trinket proc and mangle up my rupture ticks for around 1k-1100. OTOH my Envenom hits for 8-9k depending on debuffs and ups my poison proc chance.
Without mangle my rupture only does about 750 a tick
Without mangle rupture isn't worth using because I never managed to complete my T8. If I had it I could leverage my 50% buffed crit and it would be worth using again even without mangle. As I complete my T9 (because it's accessible and T8 isn't) rupture will become even less useful and I'll stop using it completely unless there's a really good reason (like I won't be able to hit the boss for a few seconds because of some AoE mechanic or I have to change targets).
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