The Glyph is an excellent trinket, depending on what fight you are in. As an earlier poster said, it works wonders for melee heavy fights, it stands above other trinkets by a long shot on fights like Gormok and Yogg+0. In fights like that I use my Glyph and also the 258 Satrina's Impeding Scarab. Otherwise I would use Satrina and Heart of Iron for less melee heavy fights e.g. Firefighter.
Also as another poster said earlier, don't be lazy, swap your trinkets for different fights.
And the fires of heaven scour the earth...
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