Glyph of Disease is simply not a good talent for blood. I know it's "subjective", but as someone who has run hundreds of specs and setups for maximization of threat (and achieved the highest recorded values for blood DK's on virtually every fight in the game), that's my opinion.
Glyph of Rune Strike - Glyph of Death Strike should always be standard, with Glyph of Vamp blood Or Glyph of Dark Death for the third depending on how threat or survival oriented you want to go (Glyph of Dark Death is pretty minimal, I normally stay Vamp Blood even with a Necrosis Threat Spec).
1/5 Necrosis isn't worthwhile. Subversion on the other hand is always worthwhile. Heart Strike is close to Rune Strike for generated threat with MoM and 3/3 Sub, and they are the biggest TPS majority in the arsenal.
Talent Calculator - World of Warcraft for progression TPS.
Talent Calculator - World of Warcraft for absolute maximum.


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