I shifted my movement keys over to ESDF which allows me to bind all the keys around those. My big 3 abilities are bound to G, T, and R, with R being a revenge/HS macro. I generally slam R or V (cleave) 3 or 4 times between each GCD. It's effective and keeps me focused and awake. I gotta try the mouse wheel binding though, seriously that is brilliant.
Oh yeah and my TC is bound to 3 (carry over from my pally days when 3 was consecrate).