Clicking is fine for some abilities but it's something you definitely want to move away from for your most important abilities. There are some movement fights that will be near impossible if you are still clicking.
Here's how I started. The 1-5 keys were my hotkeys that I learned first. I put my most important abilities onto the hotbar, in roughly this order:
2: Shield Block
3: Shield Slam
5: Sunder (or Devastate)
Getting used to those 5 isn't terribly hard and it will make you a better player by learning to do it. There are unfortunately some times when you must turn and move while keeping shield block up and using other abilities.