Nuke

My 4 main attacks are all macroed with Rune Strike. Example:
#showtooltip
/cast Icy Touch
/cast Rune Strike

Keybindings:
1 - Icy Touch
2 - Plague Strike
3 - Blood Strike
4 - Scourge Strike
5 - Dark Command
6 - Horn of Winter
7 - Empowered Rune Weapon
Mouse Button 4 - IBF
Mouse Button 5 - Blood Tap
Q - Death Coil
E - Death Grip

S = shift
S1 - Bone Armor
S2 - Pestilene
S3 - Unholy Blight
S4 - Blood Boil
S5 - DnD
S Mouse Button 4 - Anti Magic Zone
S Mouse Button 5 - Anti Magic Shield
SQ - Icy Chains
SE - Trinkets Macro